Stress response physiology in the cardiac patient: from the laboratory to real life.
Recognition of a "brain-heart axis" has grown substantially, highlighting the contribution of psychological stress on cardiovascular physiology and the development and progression of cardiovascular disease (CVD). This connection appears particularly consequential for individuals with established CVD…
Hives in autonomic disorders: a cutaneous marker of a distinct symptom phenotype.
Postural Orthostatic Tachycardia Syndrome (POTS) and Neurally-Mediated Hypotension (NMH) are heterogeneous syndromes characterized by dysautonomia and multisystem symptoms. Mast cell activation, often manifesting as hives, has been proposed as a contributing mechanism, but its prevalence and clinica…
Interleukin-17A Links Obesity-Induced Inflammation to Behavioral Disorders and Autonomic Imbalance.
Obesity is increasingly recognized as a chronic inflammatory condition, often driven by prolonged high-fat diet (HFD) consumption. Beyond causing metabolic dysregulation, obesity can disrupt immune-brain communication, contributing to the development of emotional disorders. During the early stages o…
Wilkie syndrome combined with nutcracker syndrome presented as syncopal episodes: A case report.
Combined aortomesenteric compression is an extremely rare vascular condition where both the duodenum (Wilkie) and the left renal vein (nutcracker) are compressed between the aorta and the superior mesenteric artery (SMA). The causal factor is the abnormal course of the SMA originating from the abdom…
Physiological and Psychological Responses in Elite Archers: Heart Rate Variability, Salivary Biomarkers, and Performance Outcomes.
This study investigated physiological responses during professional competitions by measuring heart rate variability (HRV) and salivary α-amylase and cortisol in elite archers. Based on the vagal tank theory, we examined psychophysiological dynamics and assessed differences in HRV and salivary…
Do not stop at the variant: a reversible cause of small-fiber neuropathy symptoms in an ATTRv carrier.
Presymptomatic genetic testing in relatives of hereditary transthyretin amyloidosis (ATTRv) index cases enables early carrier identification and timely treatment, but a confirmed pathogenic variant carries the risk of premature diagnostic closure when new symptoms arise. A 25-year-old asymptomatic c…
Neuropathy in Val122Ile Hereditary Transthyretin (ATTR) Amyloidosis: A Multicenter Retrospective Cohort Study.
The Val122Ile ATTR Amyloidosis has traditionally been linked to cardiac manifestations. Recent studies suggest that neuropathy may be relevant. In this study, we characterized its peripheral nerve manifestations in depth. This was a national, multicenter, observational, retrospective study. Patients…
Pregnancy outcomes in women with rheumatologic diseases and neurologic involvement.
Primary neurologic involvement represents one of the most serious manifestations of systemic autoimmune diseases, yet the influence on pregnancy outcomes remains poorly characterized across disorders. To describe neurologic disease activity and maternal-fetal outcomes in pregnancies occurring after…