Thrombin generation and the pharmacodynamics of oral anticoagulants.
Anticoagulants are essential for preventing and treating thromboembolism across a wide range of clinical settings. Yet, they share a narrow therapeutic index that demands a precise understanding of their pharmacodynamic behavior. Thrombin generation provides an integrated measure of anticoagulant ef…
Pampiniform venous plexus thrombosis in a 37 years-old male patient with severe thrombocytosis: a multifactorial aetiology.
Atypical thrombosis occurs in unconventional anatomical sites such as splanchnic, renal, gonadal, and cerebral venous vessels [1] . Genetic factors, as inherited thrombophilia could increase the risk of atypical thrombosis. Likewise, acquired disease, as cancer, autoimmune diseases (e.g. systemic lu…
This review describes recent developments in the phenotyping, monitoring, and treatment of advanced pulmonary sarcoidosis (APS), highlighting the positive strides made to recognise and treat this severe form of disease. Key to this is the use of recently described high-resolution chest computed tomo…
Metabolic Complications in Autoimmune and Autoinflammatory Diseases: Pathophysiology, Clinical Implications, and Therapeutic Perspectives.
Background and objectives: Autoimmune and autoinflammatory diseases extend far beyond their primary organ manifestations. Systemic inflammation in these disorders disrupts metabolic homeostasis, driving insulin resistance, dyslipidemia, accelerated atherosclerosis, and altered body composition. Meta…
More Than Meets the Eye: Topiramate-Induced Bilateral Secondary Angle Closure Unmasking Secondary Antiphospholipid Syndrome.
To describe a diagnostic challenge in a case of bilateral topiramate-induced secondary angle closure which led to unmasking of systemic lupus erythematosus (SLE) and secondary antiphospholipid syndrome (APS) highlighting the importance of recognizing posterior segment findings that are disproportion…
Concurrent Catastrophic Antiphospholipid Syndrome, Hemophagocytic Lymphohistiocytosis, and Myocarditis Leading to Multi-organ Failure in a Patient With Systemic Lupus Erythematosus and Antiphospholipid Syndrome.
Catastrophic antiphospholipid syndrome (CAPS) is a fulminant and life-threatening manifestation of antiphospholipid syndrome (APLS), often presenting with rapid multi-organ dysfunction and high mortality despite aggressive therapy. Its associations with hemophagocytic lymphohistiocytosis (HLH) and l…
Beyond glycaemic control: autoimmune polyglandular syndrome type 3 as an emerging distinct entity rather than a mere comorbidity in paediatric type 1 diabetes.
Autoimmune polyglandular syndrome type 3 (APS-3) is the coexistence of autoimmune thyroid disease (AITD) with type 1 diabetes (T1D) or other autoimmune diseases, after exclusion of adrenal insufficiency. We aimed to evaluate the prevalence, timeline and features of APS-3 in children and adolescents…
Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED), or Autoimmune Polyendocrine Syndrome Type 1 (APS-1), is recognized as a rare monogenic disease with an underlying etiology of biallelic mutations in the AIRE gene. Defective AIRE protein disrupts central and peripheral immune t…