Lupus (SLE)

509 papers & discussions

Systemic Lupus Erythematosus is a chronic autoimmune disease where the immune system attacks healthy tissue throughout the body.

FatigueJoint painButterfly rashPhotosensitivityKidney inflammationFlares

Research

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PubMed

E4BP4 restrains effector-memory CD8+ T cell responses in systemic lupus erythematosus.

Increasing evidence shows that CD8+ T cells are the pathogenic mediators of tissue injury in systemic lupus erythematosus (SLE), sustaining the chronic inflammation through the accumulation of long-lived cytotoxic memory populations. However, the transcriptional mechanisms that prevent the aberrant…

lupus
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PubMed

Evaluation of clinicopathological features of renal biopsies in non-lupus rheumatic diseases: a university hospital experience.

Renal involvement is a common condition in rheumatologic diseases. The aim of this study was to evaluate the clinical presentations and histopathological results in patients diagnosed with non-lupus rheumatic diseases who underwent renal biopsy. The records of 900 renal biopsies performed at our hos…

lupusraankylosing spondylitisiga nephropathy
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PubMed

A case of suspected hydroxychloroquine-induced cardiomyopathy: From therapy to toxicity.

Hydroxychloroquine (HCQ) is a cornerstone treatment for rheumatologic diseases. While it is generally well tolerated, chronic use has rarely been associated with cardiotoxicity. It is believed to occur due to the accumulation of HCQ in lysosomes, which impairs enzyme activity and eventually leads to…

lupusmixed connective tissuemyasthenia gravis
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PubMed

HSP27 in autoimmune diseases: Context-dependent regulation and clinical potential.

Heat shock protein 27 (HSP27) is a crucial member of the small heat shock protein family with a molecular weight of approximately 27 kDa, playing key roles in cellular stress response, protein homeostasis, and cell survival regulation. Recent studies have revealed that HSP27 plays a complex dual rol…

lupusramsmyasthenia gravis
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PubMed

Characterizing cutaneous manifestations of systemic autoimmune rheumatologic diseases in Filipino skin.

Cutaneous findings provide important clues to systemic autoimmune rheumatologic diseases (SARDs), but presentation varies across skin types and may be underrecognized in patients of color. In the Philippines, diagnostic challenges are amplified by limited specialists and a lack of pigmented-skin lea…

lupus
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PubMed

The role of IRF5 as an immune regulator.

Interferon regulatory factor 5 (IRF5) is a transcription factor at the nexus of immune regulation, inflammation, and autoimmune disease. Studies have shown that dysregulation of IRF5 is strongly implicated in the pathogenesis of autoimmune diseases including systemic lupus erythematosus (SLE), rheum…

lupusracrohns
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PubMed

Glymphatic dysfunction as a potential mechanistic link to cognitive ımpairment in Behçet's disease: a hypothesis.

Behçet's disease (BD) is a chronic multisystem inflammatory disease in which cognitive impairment is increasingly recognized but remains incompletely understood. Although cognitive dysfunction is more common in patients with Neuro-Behçet's disease (NBD), it has also been reported in patien…

lupusbrain fogbehcets
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PubMed

Polymorphous immunotherapy-induced cutaneous sarcoidosis.

We describe a patient who developed a cutaneous sarcoidosis-like reaction while on pembrolizumab, with both a facial lupus pernio-like rash and large subcutaneous nodules (Darier-Roussy disease) on her limbs.

lupussarcoidosis
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