Identifying EEG biomarkers of fatigue and brain fog in long COVID: insights from rest and movement-related brain activity.
Fatigue and brain fog are among the most reported symptoms in Long COVID (LC), yet their underlying neural mechanisms remain unclear. In this context, we aimed to identify neural correlates associated with LC symptoms. Electroencephalography (EEG) was used to quantify brain oscillatory activity duri…
The MIND study: Design, feasibility, and baseline characteristics of a smartphone-based migraine cohort.
Our objective was to describe the design, feasibility, and baseline characteristics of the Migraine Impact on Neurocognitive Dynamics study, a 30-day smartphone-based, prospective, decentralized, observational cohort study evaluating high-frequency assessment of cognition and symptoms in adults with…
Acemannan as a potential therapeutic agent for cognitive impairment via modulation of cholinergic, oxidative, and inflammatory pathways: in vivo and in silico evidence.
Cognitive impairment is a major feature of neurodegenerative disorders and is associated with cholinergic dysfunction, oxidative stress, neuroinflammation, and impaired neuroplasticity. Acemannan, a bioactive acetylated β-(1→4)-linked polymannan derived from Aloe vera (Aloe barbadensis…
Glymphatic dysfunction as a potential mechanistic link to cognitive ımpairment in Behçet's disease: a hypothesis.
Behçet's disease (BD) is a chronic multisystem inflammatory disease in which cognitive impairment is increasingly recognized but remains incompletely understood. Although cognitive dysfunction is more common in patients with Neuro-Behçet's disease (NBD), it has also been reported in patien…
Opioid use, disability, and patient-reported cognitive impairment in migraine: Multi-country results from the Chronic Migraine Epidemiology and Outcomes-International Study.
To characterize the population who do and do not use opioids to treat migraine in the Chronic Migraine Epidemiology and Outcomes-International (CaMEO-I) Study. Opioids are not recommended for migraine treatment because of efficacy and safety limitations. This was a post hoc analysis of CaMEO-I, an i…
Pragmatic approaches to improve the care of patients with sarcoidosis.
Sarcoidosis is associated with an increasing global burden, driven by rising prevalence, severe organ involvement, treatment-related morbidity, and substantial impairment in quality of life (QoL). Despite advances in diagnostics and therapeutics, important barriers continue to limit timely, equitabl…
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Peripheral sudomotor reflex activity as a candidate autonomic biomarker for psychosis: associations with symptoms and cognition.
Abnormalities in Autonomic Nervous System activity are well described in psychosis but their peripheral versus CNS origins remains unresolved. However, the purely peripheral component of the sudomotor sweat reflex can be quantified using the Quantitative Sudomotor Axon Reflex Test (Q-SWEAT), in whic…
Cholesterol crystal formation and embolism in the central nervous system and their potential role in Alzheimer's disease.
The brain and nervous tissues are very rich in cholesterol with local sterol biosynthesis being the primary source. The production of cholesterol in the brain may also lead to cholesterol crystal formation that in turn can cause inflammation which potentially can contribute to Alzheimer's disease. I…