The relationship between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and tubular atrophy/interstitial fibrosis in patients with IgA nephropathy.
Background: The tubular atrophy/interstitial fibrosis (T) lesions of the Oxford Classification is a key prognostic determinant in IgA nephropathy (IgAN). The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is an emerging lipid marker, but its link with r…
Thwarted credibility work and double binds in medically unexplained pain in Japan: a qualitative study.
This study examined how people living in Japan with medically unexplained pain (MUEP) perform credibility work across clinics and everyday life, where and why credibility work falters, and the interactional double binds organizing these failures. We qualitatively analyzed first-person illness narrat…
"You are not the person you used to be…". A phenomenological study on sexual desire and embodied sexuality in heterosexual women with fibromyalgia syndrome.
The objective of this study was to describe and understand how women with fibromyalgia syndrome (FMS) perceive their sexuality and the changes associated with sexual desire. A qualitative methodology based on Merleau-Ponty's phenomenology was used. Data collection included in-depth interviews with f…
From Regenerative to Degenerative Niche: Multicellular Crosstalk and Population Dynamics in Skeletal Muscle Aging.
Skeletal muscle aging is increasingly recognized as a failure of tissue-level coordination rather than a consequence of isolated defects in individual cell types. Recent advances in single-cell, spatial, and multimodal omics have revealed that aging remodels the abundance, functional states, and int…
Fibro-Adipogenic Progenitor Ablation Triggers Muscle Atrophy Through Cell Death-Induced Inflammation.
Skeletal muscle mass maintenance involves coordination of myofibers with mononuclear cell populations, including satellite cells, resident macrophages and fibro-adipogenic progenitors (FAPs). FAPs, identified by surface expression of PDGFRα, are important contributors to muscle homeostasis, as…
For decades, we have known that women, especially younger women, are disproportionately affected by pain disorders, including irritable bowel syndrome, endometriosis, menstrual migraines, fibromyalgia, osteoarthritis, and neuropathic pain, all of which degrade quality of life. The adoption of sex as…
Centrally mediated pain features predict persistent pain in early inflammatory arthritis: a 2-year prospective study.
Patients with inflammatory arthritis (IA) often report pain not necessarily coupled to active inflammation. We previously demonstrated that a significant subset of patients with newly diagnosed IA report features of centrally mediated pain. In this prospective study following the same IA cohort, we…
Faecal calprotectin for the diagnosis of bowel inflammation in patients with rheumatologic diseases: what is new in the last 5 years (2020-2025)?
This study updated the evidence (2020-2025) on the diagnostic and prognostic value of faecal calprotectin (FC) in rheumatologic diseases, focusing on spondyloarthritis (SpA), rheumatoid arthritis, and fibromyalgia syndrome. A systematic search of PubMed, Web of Science, and Cochrane databases (Janua…