Identifying EEG biomarkers of fatigue and brain fog in long COVID: insights from rest and movement-related brain activity.
Fatigue and brain fog are among the most reported symptoms in Long COVID (LC), yet their underlying neural mechanisms remain unclear. In this context, we aimed to identify neural correlates associated with LC symptoms. Electroencephalography (EEG) was used to quantify brain oscillatory activity duri…
Multimodal approach to identify neuropsychophysiological subgroups in myalgic encephalomyelitis/chronic fatigue syndrome and their relevance for rehabilitation: protocol for a mechanistic cross-sectional and longitudinal study.
Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) is a debilitating condition characterized by severe fatigue and post-exertional malaise (PEM). Reported neuropsychophysiological abnormalities suggest ME/CFS is multifactorial, but current knowledge remains fragmented. This study protocol…
Exercise lactate in post-COVID-19 condition: Pathophysiological signal, phenotyping tool, or candidate biomarker? A narrative review with a hypothesis-generating clinical observation.
Post-COVID-19 condition (PCC), commonly termed long COVID, is a heterogeneous multisystem disorder in which fatigue, exertional dyspnoea, post-exertional symptom exacerbation, and reduced exercise tolerance are prominent. No single laboratory measurement currently confirms or excludes PCC. Because l…
Exploring differences in protein cargo of extracellular vesicles from ME/CFS patient plasma compared to healthy controls.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by post-exertional malaise, fatigue and pain. Yet, its underlying biological mechanisms remain poorly understood. Extracellular vesicles (EVs) are nanoparticles carrying biological cargo a…
Sleep and Migraine Interactions in Episodic and Chronic Migraine: A Hospital-Based Cross-Sectional Study.
Migraine and sleep disturbances frequently coexist. The study aimed at characterizing sleep disturbances and their association with migraine characteristics. In this cross-sectional study, 253 patients with migraine [patients with episodic migraine (pEM) = 103 and patients with chronic migraine (pCM…
Total blood volume and red blood cell volume are not associated with orthostatic intolerance in adults with myalgic encephalomyelitis/chronic fatigue syndrome.
Orthostatic intolerance is common in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and may worsen daily functioning. Although hypovolemia has been proposed as a contributor, its relationship to objective orthostatic abnormalities remains uncertain. We examined whether measured blood-vo…
Gaps in physiotherapy capacity to provide Long COVID rehabilitation care.
Long COVID is a complex multisystemic condition often associated with persistent cardiorespiratory symptoms. Rehabilitation is key for managing symptoms, but there are questions about the capacity of rehabilitation professionals to provide effective care. This study assessed the capacity of physioth…
Guidance on Home-Based Care for People with Severe ME/CFS: A Transdisciplinary Expert Statement.
Many patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have significant care needs. However, post-exertional malaise-the defining feature of ME/CFS-means that even minor physical, orthostatic, cognitive, or sensory stressors can trigger a disproportionate worsening of symptom…