Towards standardized gut microbiota diagnostics: normobiosis beyond geographical borders.
Defining clinically meaningful reference states of the human gut microbiota remains a major barrier to the clinical translation of microbiome testing, largely due to variability across populations. We aimed at evaluating whether dysbiosis can be identified in a standardized, geography-independent ma…
Constipation with bloating: a clinical approach to evaluation and management.
Constipation and bloating are common bothersome gastrointestinal (GI) symptoms that frequently occur concurrently. It is important to recognize the underlying condition(s) and tailor therapeutic interventions appropriately. This review discusses the evaluation and management of patients with constip…
Life-course hygiene exposures and disorders of gut-brain interaction: a multinational cross-sectional study.
Despite growing interest in its role in immune-mediated diseases, the relevance of the hygiene hypothesis to disorders of gut-brain interaction (DGBI) remains unclear. We aimed to examine the associations between childhood and adulthood hygiene-related exposures and DGBI prevalence, and to assess wh…
Lactiplantibacillus Plantarum CKDB008 and Lacticaseibacillus Rhamnosus LDTM7511 Attenuate Visceral Hypersensitivity and Suppress Serum IgE in an Acetic Acid-Induced IBS-Like Rat Model.
Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by visceral hypersensitivity, impaired intestinal barrier, immune activation, and gut microbiota dysbiosis, for which standardized treatment remains limited. In this study, we evaluated Lactiplantibacillus plantarum…
Agomelatine improves symptom severity and quality of life in diarrhea-predominant irritable bowel syndrome: insights from a randomized controlled clinical trial.
Irritable bowel syndrome with diarrhea predominance (IBS-D) significantly impairs Quality of Life (QOL) and is often accompanied by psychological distress. Agomelatine, a melatonergic antidepressant, has shown promise in modulating gastrointestinal symptoms and mood disorders. This study aimed to ev…