TRANSformative perspectives on endometriosis research policy, and practice: Insights from multidisciplinary focus groups.
Transgender and gender diverse (TGD) people with endometriosis have unique health needs. Current health research, policy, and clinical practice are developed within a biomedical and cisheteronormative paradigm that structurally excludes the TGD community, whose health needs remain largely unmet. Thi…
For decades, we have known that women, especially younger women, are disproportionately affected by pain disorders, including irritable bowel syndrome, endometriosis, menstrual migraines, fibromyalgia, osteoarthritis, and neuropathic pain, all of which degrade quality of life. The adoption of sex as…
The endometriosis-POTS connection: A retrospective analysis.
To report the prevalence of endometriosis among female patients with postural orthostatic tachycardia syndrome (POTS) and determine which condition is more commonly diagnosed first. In a retrospective case-control analysis, we reviewed medical records for patients with POTS who presented to our auto…
Prevalence and Impact of Pelvic Floor Dysfunction in a Large Cohort of Patients with Endometriosis: The Hidden Link
A survey of 525 women with confirmed endometriosis found pelvic floor dysfunction in the large majority: 83.8% reported sexual dysfunction, 65.9% moderate-to-severe urinary symptoms, and 66.3% moderate-to-severe bowel symptoms. The authors describe this as an underdiagnosed and undertreated part of…
Adhesive Versus Spatial Anatomical Distortion Determines Energy Device Performance in Complex Total Laparoscopic Hysterectomy.
To evaluate whether the type of anatomical distortion-spatial or adhesive-determines the relative performance of the energy device in complex total laparoscopic hysterectomy (TLH). Retrospective cohort study. Single tertiary referral center. A total of 167 women who underwent complex TLH between 201…
A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair.
There is a higher density of immune cells in peritoneal fluid than is found in blood. Thus, any perturbations, from sterile injury to endometriosis to ovarian cancer, require immune cells to recognize and nucleate to these sites. Using peritoneal injuries as a prototype, we saw a massive recruitment…
Generation and Characterization of a Rdh1-iCre Line to Study Uterine Glandular Biology.
The uterus is an essential organ for fetal development in most mammals. Uterine glands, highly conserved structures in the mammalian uterus, play critical roles in the establishment and maintenance of pregnancy and have been implicated in the pathogenesis of uterine diseases, including endometrial c…