Safety monitoring of bivalent, quadrivalent, and 9-valent human papillomavirus vaccination in Japan: The vaccine effectiveness, networking, and universal safety (VENUS) study.
Safety data on human papillomavirus (HPV) vaccination in the Japanese population remain limited owing to the lack of healthcare databases available for vaccine safety assessment. In this study, we assessed the risk of adverse events of special interest (AESIs) following HPV vaccination among females…
Restoring ovulation in functional hypothalamic amenorrhea: impact of polycystic ovarian morphology on hormonal response to pulsatile GnRH.
Up to 50% of women with functional hypothalamic amenorrhea (FHA) exhibit polycystic ovarian morphology (PCOM) on ultrasound. We aimed to compare the hormonal response to ovulation induction with pulsatile GnRH therapy in FHA patients with and without PCOM. In this single-center observational study,…
Association of ERBB4 and SHBG gene polymorphisms with polycystic ovarian syndrome in South Indian women: a case-control genetic analysis.
Polycystic ovary syndrome (PCOS) is a multifactorial endocrinological disorder with a substantial genetic component. However, the role of genes involved in follicular development and androgen regulation remains incompletely understood, particularly in South Indian populations. This study aimed to ev…
Variation in gestational outcomes among PCOS phenotypes in natural and art-conceived pregnancies.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. While diagnostic criteria have historically varied, the Rotterdam criteria, established in 2003, are now the standard. This classification identifies four PCOS phenotypes based on the presence…
Vitamin D regulates lipid metabolism in granulosa cells via the FABP3-associated PI3K/Akt pathway in polycystic ovary syndrome.
To investigate whether vitamin D (VD) affects lipid metabolism in granulosa cells in polycystic ovary syndrome (PCOS) through the FABP3-associated PI3K/Akt pathway. PCOS rat models were established using letrozole, followed by ovarian transcriptome sequencing, which revealed significant enrichment o…
OGN inhibits apoptosis and ferroptosis via FSHR in human granulosa cells: implications for polycystic ovary syndrome.
Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by granulosa cell dysfunction, including impaired proliferation, excessive apoptosis, and ferroptosis, which contribute to abnormal follicular development and ovarian dysfunction. This study aims to investigate…
Toward AI-Driven Detection of Asymptomatic Chronic Conditions from Stool Metagenomics and Dietary Data: A Multimodal Deep Learning Framework for T1DM, T2DM, MOS/PCOS, Cancer, and Autoimmune Disease.
Chronic non-communicable conditions-type 1 and type 2 diabetes mellitus (T1DM, T2DM), metabolic obesity syndrome (MOS), polycystic ovary syndrome (PCOS), colorectal and extra-intestinal cancers, and systemic autoimmune disease-share a prolonged asymptomatic phase during which conventional screening…