Stepwise management of median arcuate ligament syndrome with visceral artery aneurysm: Surgical ligament release followed by percutaneous transluminal angioplasty.
A woman in her 20s presented with an 8-year history of postprandial abdominal pain. Contrast-enhanced computed tomography revealed severe stenosis at the origin of the celiac artery, collateral circulation from the superior mesenteric artery, and an associated inferior pancreaticoduodenal artery ane…
The Gut-Liver Immune Axis in Celiac Disease, Primary Sclerosing Cholangitis, and Ulcerative Colitis: Outcomes of a Rare but Significant Triad.
Purpose To characterize the clinical presentation, disease course, and outcomes of patients with concurrent primary sclerosing cholangitis (PSC) and celiac disease (CeD), including those with concomitant inflammatory bowel disease (IBD). Methods Retrospective EHR analysis (MGB RPDR, BIDMC Celiac Cen…
Irritable bowel syndrome (IBS) is one of the most prevalent disorders of gut-brain interaction, characterized by recurrent abdominal pain or abdominal discomfort associated with altered bowel habits in the absence of identifiable structural disease. IBS affects ~4-11% of the global population and is…
Potential Celiac Disease as a Window Into Gluten-Mediated Enteropathy.
Potential celiac disease is defined as having positive celiac serology in the absence of intestinal villous atrophy. This phenotype is common, accounting for ∼1 in 5 celiac patients. Many patients never develop the enteropathy characteristic of active celiac disease, and antibodies may even n…
Mid-term Outcomes of Asymptomatic and Symptomatic Isolated Mesenteric Artery Dissections.
Isolated spontaneous mesenteric artery dissections present with a broad spectrum of symptoms and are increasingly detected due to the widespread use of computed tomography. Treatment options are debated, from observation and medical management to endovascular procedures and open surgery. A retrospec…
The Immunological Intersection of Psoriasis and Autoimmune Diseases: Shared Pathways and Clinical Implications.
Psoriasis is a chronic inflammatory disease associated with multiple autoimmune conditions. This article reviews the relationship between psoriasis and autoimmune blistering dermatoses, vitiligo, alopecia areata, autoimmune thyroid disorders, systemic lupus erythematosus, and celiac disease, highlig…
Beyond glycaemic control: autoimmune polyglandular syndrome type 3 as an emerging distinct entity rather than a mere comorbidity in paediatric type 1 diabetes.
Autoimmune polyglandular syndrome type 3 (APS-3) is the coexistence of autoimmune thyroid disease (AITD) with type 1 diabetes (T1D) or other autoimmune diseases, after exclusion of adrenal insufficiency. We aimed to evaluate the prevalence, timeline and features of APS-3 in children and adolescents…
A dual-mode electrochemical-colorimetric aptasensor based on HCR-CRISPR/Cas12a cascade amplification for MTGase detection.
Microbial transglutaminase (MTGase) is widely used in food processing, but its potential food safety risks cannot be neglected. MTGase-treated wheat products show immunoreactivity, which may induce celiac disease and damage intestinal barrier function. Therefore, trace detection of MTGase is of grea…