Complications and Management of Ehlers-Danlos Syndromes and Hypermobility Spectrum Disorders: A Literature Review.
Ehlers-Danlos syndrome (EDS) is a group of inherited disorders affecting collagen and extracellular matrix proteins, which can cause skin hyperelasticity, joint hypermobility, atrophic scarring, and blood vessel fragility. Complications include joint dislocation, chronic pain, fatigue, functional ga…
Real-world all-cause healthcare resource utilization and costs among patients with interstitial cystitis/bladder pain syndrome in the United States.
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a persistent and heterogeneous condition diagnosed by exclusion, defined by a bladder-associated unpleasant sensation (e.g. pain, pressure, or discomfort), and affecting patients' quality of life. This real-world study aimed to describe all-cau…
Efficacy analysis of combined nerve combing and decompression for occipital neuralgia based on the classification of neurovascular relationships.
This study set occipital pain improvement as the primary endpoint, and overall headache relief, migraine index, medication use and complication rate as secondary endpoints, to evaluate the efficacy and safety of neural combing plus decompression guided by four neurovascular relationship subtypes for…
A meta-analysis of pain intensity changes after placebo interventions in facial pain.
Interpreting pain improvements after interventions in clinical settings is challenging because placebo effects can influence patient-reported outcomes. In clinical practice, pain intensity reductions of 30% or greater are commonly considered indicative of meaningful analgesic benefit. However, the l…
Thwarted credibility work and double binds in medically unexplained pain in Japan: a qualitative study.
This study examined how people living in Japan with medically unexplained pain (MUEP) perform credibility work across clinics and everyday life, where and why credibility work falters, and the interactional double binds organizing these failures. We qualitatively analyzed first-person illness narrat…
Management of Neuropathic Pain in Complex Regional Pain Syndrome: A Comprehensive Review.
Complex regional pain syndrome (CRPS) is a complex and multifaceted condition in which pain may be neuropathic, nociplastic, nociceptive, or mixed in nature. This review aims to summarize the available pharmacological and non-pharmacological strategies for managing neuropathic pain in CRPS Types I a…
Thermosensitive hydroxypropyl chitin-based hydrogel for trigeminal neuralgia: Rapid analgesia, myelin repair, and attenuation of gamma-band hyperactivity in the spinal trigeminal nucleus caudalis.
Trigeminal neuralgia is a debilitating neuropathic disorder characterized by the complex interplay of peripheral demyelination and central sensitization. Current pharmacotherapies remain palliative, limited by systemic toxicity and an inability to reverse pathological microenvironments. Herein, an i…
From compression to denervation: Multimodality imaging of cervical rib-related arterial thoracic outlet syndrome.
Thoracic outlet syndrome (TOS) encompasses a spectrum of disorders caused by compression of neurovascular structures at the thoracic outlet. Arterial thoracic outlet syndrome (aTOS) is rare, accounting for less than 1% of cases, yet carries significant morbidity due to arterial injury, thrombosis, a…