Safety monitoring of bivalent, quadrivalent, and 9-valent human papillomavirus vaccination in Japan: The vaccine effectiveness, networking, and universal safety (VENUS) study.
Safety data on human papillomavirus (HPV) vaccination in the Japanese population remain limited owing to the lack of healthcare databases available for vaccine safety assessment. In this study, we assessed the risk of adverse events of special interest (AESIs) following HPV vaccination among females…
Efficacy analysis of combined nerve combing and decompression for occipital neuralgia based on the classification of neurovascular relationships.
This study set occipital pain improvement as the primary endpoint, and overall headache relief, migraine index, medication use and complication rate as secondary endpoints, to evaluate the efficacy and safety of neural combing plus decompression guided by four neurovascular relationship subtypes for…
Serum Concentration Relationships of Candesartan in Migraine Prevention.
Migraine is a common disabling disorder, and optimising affordable preventive treatments remains highly relevant. Candesartan is an effective and well-tolerated preventive treatment, but little is known about its dose-concentration-response relationships. We explored these relationships using data f…
The MIND study: Design, feasibility, and baseline characteristics of a smartphone-based migraine cohort.
Our objective was to describe the design, feasibility, and baseline characteristics of the Migraine Impact on Neurocognitive Dynamics study, a 30-day smartphone-based, prospective, decentralized, observational cohort study evaluating high-frequency assessment of cognition and symptoms in adults with…
Plasma amylin levels in migraine and after erenumab treatment: A REFORM study.
To investigate whether plasma amylin concentrations differ between adults with migraine and healthy controls (HCs) and whether baseline or longitudinal amylin levels are associated with treatment response to erenumab. Amylin is a calcitonin family peptide closely related to calcitonin gene-related p…
Greater occipital nerve block versus intranasal sphenopalatine ganglion block in chronic migraine with failure of at least two oral preventive treatments: a prospective, non-randomised patient-preference comparative study.
Prospective comparative evidence for greater occipital nerve (GON) block and intranasal sphenopalatine ganglion (SPG) block is limited. This study describes the six-month course of two treatment cohorts of patients with chronic migraine in whom at least two oral preventive treatments had failed. To…
When does empathy help? Patient-perceived physician empathy and migraine severity.
Migraine is one of the most common neurological disorders and the second leading cause of disability worldwide. While it is known that psychosocial factors play an important role in illness, it is not clear how they are related to patients' perceptions of clinician empathy. We aimed to examine the r…
The burden of noncommunicable and injury-related nervous system disorders in the Americas, 1990-2023: an analysis of the Global Burden of Disease Study 2023.
Noncommunicable and injury-related nervous system disorders (NINSDs)-including cerebrovascular and neurodegenerative diseases, neurodevelopmental disorders, neuromuscular conditions, brain cancers, and traumatic brain injuries-are major contributors to morbidity, disability, and premature mortality…