Coenzyme Q10 Supplementation May Be Correlated With Resolution of New Daily Persistent Headache.
New daily persistent headache is a chronic, treatment-resistant primary headache disorder with limited guidance on effective management. Despite its significant impact on headache-related quality of life, few studies have identified targeted therapies that contribute to symptom resolution. This stud…
Calvarial Metastasis of Breast Carcinoma Manifesting as a New Daily Persistent Headache: A Case Report.
New-onset daily persistent headache (NDPH) is a primary headache syndrome characterized by a sudden onset of daily headaches persisting for more than three months in patients with no prior headache history. We report the case of a 49-year-old Indian lady who presented to the neurology outpatient cli…
A foundation-model approach to pediatric headache classification from resting-state fMRI.
Headache is the most common neurological disorder in children and substantially affects quality of life. We investigated whether resting-state functional MRI (rs-fMRI) can support pediatric headache classification using machine learning. We encoded rs-fMRI data using NeuroSTORM, a recent foundation…
Diagnostic uncertainty in severe continuous headache: Examining the overlap between status migrainosus, new daily persistent headache, and refractory migraine.
When a headache becomes severe and does not stop for months, the diagnosis is not always clear, even when it seems like migraine. Current definitions of status migrainosus, new daily persistent headache, and refractory migraine overlap, so one patient may fit more than one diagnosis at the same time…
Treatment outcomes in new daily persistent headache in children and adolescents.
BackgroundNew daily persistent headache (NDPH) is a primary headache disorder that often presents in adolescence. Presently, there is no effective treatment for NDPH and a paucity of clinical trials exploring therapeutic options. In this study, we explored the relative benefit of currently used trea…
Patient reported trigger, not the speed of transition to continuous headache, is associated with headache-related disability in children: Results of a cross-sectional clinic-based study.
ObjectiveTo investigate the relationship between the evolution of continuous headache and headache-related disability in children.MethodsThis was a single site cross-sectional study using patient-entered questionnaires from children aged 6-17 who presented to neurology clinic between November 2022-M…
Pediatric New Daily Persistent Headache: Integrating Novel Research Methods to Support and Delineate Evolving Clinical Phenotypes.
Pediatric new daily persistent headache (NDPH) is a clinically defined headache subtype that remains controversial due to a lack of unique and objective mechanistic features. For many headache subtypes, different, and sometimes unique, patterns of structural and functional changes can be observed in…
Long COVID Syndrome and Associated New Daily Persistent Headache (NDPH) Presenting With Crossed Clonus Response.
Evaluating patients following a COVID-19 infection with multiple chronic, progressive symptoms can be challenging, but easy to navigate by using the temporal profile obtained from the clinical history, findings from the neurological exam, and screening for red flag symptoms.