GLP-1 agonists before endoscopy: separating fact from fiction.
Glucagon-1 receptor agonists (GLP-1A) delay gastric emptying, which has raised concerns about heightened risk of increased residual gastric volume (RGV) despite appropriate fasting measures. RGV could increase risk of pulmonary aspiration during sedated procedures like upper endoscopy. The purpose o…
Pan-European Training Program for Robotic Pancreatoduodenectomy (LEARNBOT): Prospective Multicenter Study on Feasibility and Outcome.
To assess the feasibility of and clinical outcomes after a pan-European training program for robotic pancreatoduodenectomy (RPD). The implementation of RPD into clinical practice comes with considerable challenges, leading to concerns about patient safety, oncological outcomes, and costs. To address…
Impact of Side-to-Side Versus End-to-Side Gastrojejunostomy on the Rate of Delayed Gastric Emptying After Pancreatoduodenectomy (IPAD study): A Randomized Controlled Trial.
To evaluate whether side-to-side gastrojejunostomy (SSGJ) reduces delayed gastric emptying (DGE) compared with end-to-side gastrojejunostomy (ESGJ) after pancreatoduodenectomy (PD). DGE is one of the most frequent complications after PD, leading to prolonged recovery and increased morbidity. Retrosp…
Insights into natural dietary components as indirect modulators of glucagon-like Peptide-1 receptor signaling in weight management.
The glucagon-like peptide-1 receptor (GLP-1R) has emerged as a major therapeutic target in obesity and metabolic disease due to its roles in appetite regulation, gastric emptying, insulin secretion, and energy homeostasis. Although pharmacological GLP-1R agonists produce substantial weight reduction…
The learning curve of robotic pancreatoduodenectomy: a systematic review of learning curve assessment methodologies, proficiency thresholds, training pathways and clinical outcomes.
Robotic pancreatoduodenectomy (RPD) is one of the most technically challenging procedures in hepatopancreatobiliary surgery. Its adoption continues to grow, but the learning pathway to competency and mastery is still not fully defined. This systematic review aims to analyze the learning curve assess…
Gastrointestinal adverse effects of GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists: A narrative expert review of approved therapies, oral formulations, and pipeline agents.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonists have transformed the management of type 2 diabetes and obesity. Gastrointestinal (GI) adverse events are the most common limitation of these therapies and a leadi…
Early postoperative outcomes after hybrid minimally invasive pancreaticoduodenectomy with a mini-laparotomy reconstruction: a single-centre randomised feasibility trial.
Minimally invasive pancreaticoduodenectomy is being increasingly adopted over the traditional open approach, but this adoption remains limited by a steep learning curve and the need for safe pancreatic and biliary reconstruction. This pilot randomised study evaluated the technical feasibility and sa…
Efficacy and safety of Braun enteroenterostomy in patients undergoing pancreatoduodenectomy: a systematic review and meta-analysis.
Delayed gastric emptying (DGE) is a common complication after pancreatoduodenectomy (PD). Braun enteroenterostomy (BEE) has been proposed as an adjunct to reduce DGE. This meta-analysis aims to evaluate the safety and efficacy of BEE in patients undergoing PD. CINAHL, PubMed, Embase, Scopus, Web of…