A hydrogel ionic circuit electrical stimulation system to restore denervated muscle following long-gap peripheral nerve injury.
Electrical stimulation (EStim) has been used to exercise denervated muscle pending nerve regeneration, to prevent muscle atrophy. However, higher EStim intensity is required to achieve maximal therapeutic efficacy, which is challenging because conventional electrodes generate heat and alter pH, pote…
Ramadan fasting in patients with primary adrenal insufficiency: evaluation of the risk of complications, quality of life and sleep, and associated factors.
The study aimed to evaluate the risk of complications, quality of life (QoL) and quality of sleep (QoS) during Ramadan fasting (RF) in patients with primary adrenal insufficiency (PAI) and determine the associated factors. It was an interventional, randomised, crossover, self-controlled study, inclu…
Nocturnal sleep-related scratching disorder as a possible variant of NREM arousal disorder: Clinical features and polysomnographic study of four newly reported cases.
A clinical variant of NREM arousal disorder is described manifesting with predominantly injurious, and exclusively sleep-related scratching without any conscious awareness, and without a history of dermatologic disease. Four patients were clinically evaluated and underwent videopolysomnography (vPSG…
Glehnia littoralis and imperatorin attenuate allergic airway inflammation via mast cell stabilization and transcriptome-defined suppression of FcεRI/TLR-MAPK/NF-κB signaling.
Allergic airway inflammation is driven by mast cell activation and IgE-FcεRI signaling. Current pharmacological treatments often present limited efficacy or long-term adverse effects. Glehnia littoralis Fr. Schmidt ex Miq. (GL) is a traditional medicinal herb used for respiratory ailments, but its a…
Serum Concentration Relationships of Candesartan in Migraine Prevention.
Migraine is a common disabling disorder, and optimising affordable preventive treatments remains highly relevant. Candesartan is an effective and well-tolerated preventive treatment, but little is known about its dose-concentration-response relationships. We explored these relationships using data f…
A case of suspected hydroxychloroquine-induced cardiomyopathy: From therapy to toxicity.
Hydroxychloroquine (HCQ) is a cornerstone treatment for rheumatologic diseases. While it is generally well tolerated, chronic use has rarely been associated with cardiotoxicity. It is believed to occur due to the accumulation of HCQ in lysosomes, which impairs enzyme activity and eventually leads to…
Percutaneous balloon compression followed by perineural methylprednisolone for trigeminal neuralgia: A 50-patient retrospective series with 12-month outcomes.
To describe pain outcomes and safety after a combined protocol of percutaneous balloon compression (PBC) followed immediately by perineural methylprednisolone in adults with pharmacoresistant trigeminal neuralgia. We conducted a multicentre, single-arm, retrospective observational series without a c…
Comparison of the efficacy of varespladib and coral snake antivenom against the activities of the Amazon coral snake (Micrurus spixii) venom.
The ability of varespladib (VPL), a phospholipase A2 (PLA2) inhibitor, to attenuate several activities of the Amazon coral snake (Micrurus spixii) venom was assessed. The neutralization by VPL was compared to that of coral snake antivenom and, in some cases, neostigmine. The venom showed anticoagula…