Myositis

220 papers

An inflammatory muscle disease causing progressive muscle weakness and inflammation.

Muscle weaknessMuscle painFatigueDifficulty swallowingSkin rashJoint pain

Research

220
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PubMed

Clinical and genetic analysis of a family with 16p11.2 microduplication syndrome and variable multisystem manifestations.

16p11.2 microduplication syndrome (OMIM #614671) is a pathogenic recurrent copy-number gain at the 16p11.2 locus and is associated with variable expressivity across neurodevelopmental, growth, and medical phenotypes. Gastrointestinal symptoms have been reported in carrier cohorts, but detailed docum…

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PubMed

Extensive dystrophic calcinosis in dermatomyositis with concurrent breast carcinoma: an imaging pitfall.

Dermatomyositis is a rare idiopathic inflammatory myopathy. Long-standing disease may be complicated by progressive dystrophic calcinosis. The association of extensive calcinosis with underlying malignancy remains exceptionally rare and diagnostically challenging. A 63-year-old woman with a 15-year…

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PubMed

Novel therapies for refractory idiopathic inflammatory myopathy-associated interstitial lung disease.

Idiopathic inflammatory myopathies (IIM) are systemic autoimmune rheumatic diseases in which interstitial lung disease (ILD) is a frequent extra-muscular manifestation and a major driver of morbidity and mortality. ILD occurs most commonly in antisynthetase syndrome and anti-melanoma differentiation…

myositisrelapsing polychondritis
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PubMed

The current clinical trial landscape in idiopathic inflammatory myopathies.

In recent years, advances in the understanding of idiopathic inflammatory myopathies (IIM) pathogenesis have led to the development of targeted therapies directed against key immune pathways. This review highlights recent advances in clinical trials, emerging therapeutic strategies, and the rapidly…

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PubMed

Dermatomyositis as a Paraneoplastic Syndrome Secondary to Carcinoma of Cervix: A Rare Clinical Association.

Dermatomyositis (DM) is a rare idiopathic inflammatory myopathy characterized by symmetric proximal muscle weakness and distinctive cutaneous manifestations. It is frequently associated with underlying malignancies, making recognition of paraneoplastic features crucial. We report the case of a 61-ye…

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PubMed

Sjögren disease and idiopathic inflammatory myopathy overlap presenting as complement-mediated thrombotic microangiopathy/atypical haemolytic uremic syndrome with a complement factor B variant: A case report.

Complement-mediated thrombotic microangiopathy (CM-TMA) is often triggered by autoimmune diseases; however, reports of CM-TMA in patients with Sjögren disease (SjD) and idiopathic inflammatory myopathy (IIM) are limited. We describe the case of a 48-year-old woman with overlapping SjD and IIM w…

myositis
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PubMed

Paraneoplastic dermatomyositis preceding detection of metastatic oesophageal squamous cell carcinoma after prolonged remission following pembrolizumab therapy.

Dermatomyositis is a recognised paraneoplastic inflammatory myopathy although its association with oesophageal malignancy is uncommon. Most reported cases either precede or accompany the initial diagnosis of malignancy. We report a man in his late fifties with previously treated oesophageal squamous…

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PubMed

All-cause mortality in statin-associated immune-mediated necrotizing myopathy compared with idiopathic inflammatory myopathy.

Statin-associated immune-mediated necrotizing myopathy (IMNM) is a distinct idiopathic inflammatory myopathy (IIM) associated with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies. The present study determined all-cause mortality among patients with statin-associated IMNM…

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