The relationship between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and tubular atrophy/interstitial fibrosis in patients with IgA nephropathy.
Background: The tubular atrophy/interstitial fibrosis (T) lesions of the Oxford Classification is a key prognostic determinant in IgA nephropathy (IgAN). The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is an emerging lipid marker, but its link with r…
Assessing the proinflammatory potential of sterile fecal microbiome filtrate from ulcerative colitis patients using an intestine-on-chip platform and automated image analysis.
Ulcerative colitis (UC) is characterized by disruptions of the gut microbiome and an exaggerated mucosal immune response in genetically susceptible individuals. Alterations in the composition of the intestinal metabolome associated with dysbiosis can trigger chronic inflammation. However, it remains…
Baicalein solid dispersion prepared by solvent evaporation enhances oral bioavailability and alleviates ulcerative colitis.
Baicalein (BAC) is a flavonoid compound known for its effectiveness in treating ulcerative colitis (UC). However, its clinical application is limited by poor water solubility, low stability, and low oral bioavailability. In this study, a baicalein solid dispersion (BAC-SD) was prepared using Polyvin…
Unraveling the Clinical Puzzle of Cerebral Venous Sinus Thrombosis in Ulcerative Colitis: Insights from a Systematic Review.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that primarily affects the colon. Among its extraintestinal complications, cerebral venous sinus thrombosis (CVST) is a rare yet potentially life-threatening emergency that can manifest as headaches, seizures, and/or neurological…
Magnetic resonance enterography (MRE) is a key noninvasive imaging modality for the diagnosis and longitudinal assessment of inflammatory bowel disease (IBD), particularly Crohn's disease. The global burden of IBD is increasing, with millions affected in North America and Europe and rapidly rising i…
Capsulectomy at Explant: Rethinking Spinal Cord Stimulator Infected Generator Pocket Management in the Immunocompromised-A Case Series.
Surgical site infections (SSI) associated with spinal cord stimulation (SCS) implants pose risks of morbidity, mortality, and increased healthcare costs. Immunocompromised patients are especially vulnerable due to impaired immune responses, delaying diagnosis and increasing complications. Current gu…
Fatigue burden and patient attribution across remission states in inflammatory bowel disease: a longitudinal cohort study.
Fatigue is common in inflammatory bowel disease (IBD), but prior work has largely focused on symptomatic disease activity rather than progressively objective remission states. We evaluated the relationship between fatigue and hierarchical remission depth, repeated changes in remission status, and pa…
The Gut-Liver Immune Axis in Celiac Disease, Primary Sclerosing Cholangitis, and Ulcerative Colitis: Outcomes of a Rare but Significant Triad.
Purpose To characterize the clinical presentation, disease course, and outcomes of patients with concurrent primary sclerosing cholangitis (PSC) and celiac disease (CeD), including those with concomitant inflammatory bowel disease (IBD). Methods Retrospective EHR analysis (MGB RPDR, BIDMC Celiac Cen…