Anticancer effects of tangeretin associated with reactive oxygen species generation, mitochondrial dysfunction and apoptosis in CaSki cells.
Cervical cancer is the fourth most common cancer and the fourth leading cause of cancer‑related mortality among women worldwide. Tangeretin (TAN), a polymethoxylated flavonoid derived from citrus fruit peel, exhibits relatively high structural stability due to its methoxy groups and exerts anticance…
A mitoxyperiosis-associated gene signature correlates with immune disturbance and provides a potential diagnostic biomarker for systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease with complex pathogenesis. Mitochondrial dysfunction and aberrant cell death are key drivers, but the mitoxyperiosis pathway has not been explored in SLE. This study aimed to evaluate mitoxyperiosis-associated gene expression in…
Peripheral endotoxemia is associated with microglial activation, neuronal apoptosis, and amyloid precursor protein accumulation.
Chronic microglial activation and the resulting neuroinflammatory cascade drive Alzheimer's disease (AD) progression. Systemic lipopolysaccharide (LPS) triggers robust microglial responses and is linked to neurodegenerative disorders, yet the full spectrum of neuroinflammatory and neuronal changes a…
Metabolic reprogramming in neuromyelitis optica spectrum disorder: From astrocyte dysfunction to immune-mediated neuroinflammation.
Neuromyelitis optica spectrum disorders comprise a group of autoimmune diseases of the central nervous system, defined primarily by astrocyte injury mediated by anti-aquaporin-4 antibodies. Although targeted therapies directed against B cells, complement, and inflammatory mediators have substantiall…
Targeting mitochondrial dysfunction and apoptosis in 5-fluorouracil-induced cardiotoxicity using kaempferol-mediated selenium nanoparticles.
5-Flurouracil (5-FU) is still considered as one of the most popular antimetabolite chemotherapy drugs to treat a wide variety of solid tumors. Dose limiting toxicity on major organs, especially cardiovascular system limits the therapeutic use of 5-FU. The current paper addresses the cardioprotective…
Alterations of endothelial cell bioenergetics in congenital diaphragmatic hernia.
Pulmonary vascular development in congenital diaphragmatic hernia (CDH) is characterized by impaired angiogenesis and pathologic remodeling that contribute to pulmonary hypertension/hypoplasia. Mitochondria regulate endothelial energy, redox balance, and angiogenic signaling, suggesting a role in CD…
WIPButyrate produced by the Lycium ruthenicum polysaccharide alleviated sleep deprivation-induced chronic fatigue syndrome in mice through promoting microglial autophagy.
This study explored whether Lycium ruthenicum polysaccharide (LRP) influences gut microbiota-derived short-chain fatty acids (SCFAs) and neuroinflammatory responses in a sleep deprivation-induced CFS-like mouse model. Oral LRP was associated with improved fatigue-related behavioral performance, redu…
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