Capillary serum-based spectroscopic signature for multiple sclerosis: A novel diagnostic perspective.
To analyze the biochemical characteristics of capillary blood-derived serum using Fourier-transform infrared (FTIR) spectroscopy, aiming to differentiate individuals diagnosed with Multiple Sclerosis (MS) from a matched control group (CG). The study included 52 patients with confirmed MS and 52 heal…
miRNA-34b overexpression alleviates neuromyelitis optica spectrum disorders by regulating the TIA-1-stress granule pathway.
Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune demyelinating diseases of the central nervous system. The role of microRNA-34b (miR-34b) in NMOSD pathogenesis remains unclear. This study investigates the expression and functional mechanism of miR-34b in NMOSD, specifically its regulat…
Molecular Identification of Transthyretin Amyloid in Fixed Skin Biopsies: A Simplified Sample Preparation Method.
Hereditary transthyretin (TTR) amyloidosis (ATTRv) is associated with peripheral neuropathy resulting from the accumulation of fibrillar TTR amyloid deposits in tissues including peripheral nerves and skin. Accurate diagnosis requires molecular identification of amyloid deposits in tissue specimens.…
Division Specific Biologically Effective Dose Predicts Gamma Knife Radiosurgery Outcomes in Multiple Sclerosis-Associated Trigeminal Neuralgia.
Outcomes after Gamma Knife surgery (GKS) for multiple sclerosis-related trigeminal neuralgia type 1 (MS-TN1) remain variable, and the role of biologically effective dose (BED) distribution across trigeminal nerve subregions is not well defined. This study evaluated whether BED-based volumetric param…
The efficacy of surgical interventions for trigeminal neuralgia in multiple sclerosis: A systematic review.
Trigeminal neuralgia affects approximately 3% of patients with multiple sclerosis - a far higher prevalence than in the general population. The associated pain often proves refractory to medication, prompting consideration of neurosurgical intervention. The variable efficacy, tolerability, and durab…
Investigating the mechanism of Xiongfu formula and its active ingredient Z-Ligustilide alleviates chronic migraine by modulating the MAPK/ERK/CREB pathway and microglia-mediated neuroinflammation.
Chronic migraine is a recurrent throbbing headache, which is often attributed to stagnated Qi and impaired blood circulation from the perspective of traditional Chinese medicine. Xiongfu formula (CRCR), consisting of Chuanxiong Rhizoma and Cyperi Rhizoma, is a classic herbal formula in treating migr…
The burden of noncommunicable and injury-related nervous system disorders in the Americas, 1990-2023: an analysis of the Global Burden of Disease Study 2023.
Noncommunicable and injury-related nervous system disorders (NINSDs)-including cerebrovascular and neurodegenerative diseases, neurodevelopmental disorders, neuromuscular conditions, brain cancers, and traumatic brain injuries-are major contributors to morbidity, disability, and premature mortality…
A Faster Way to Diagnose Multiple Sclerosis: The Central Vein Sign in Routine Clinical Practice.
The central vein sign (CVS) was included in 2024 McDonald criteria but remains underutilized in clinical practice. Implementation of CVS may reduce the requirement for lumbar punctures (LPs). At Nottingham, UK academic multiple sclerosis (MS) center, we implemented a fast-track (FT) pathway incorpor…