Evaluation of clinicopathological features of renal biopsies in non-lupus rheumatic diseases: a university hospital experience.
Renal involvement is a common condition in rheumatologic diseases. The aim of this study was to evaluate the clinical presentations and histopathological results in patients diagnosed with non-lupus rheumatic diseases who underwent renal biopsy. The records of 900 renal biopsies performed at our hos…
Sharp recanalization of extensive multilevel central venous occlusions in a young patient with familial Mediterranean fever: A case report.
Chronic multilevel central venous occlusion (CVO) in young adults is uncommon and presents major challenges in establishing reliable vascular access. Patients with recurrent thrombosis develop extensive collateral formation and progressive loss of venous access. Although familial Mediterranean fever…
Assessing the proinflammatory potential of sterile fecal microbiome filtrate from ulcerative colitis patients using an intestine-on-chip platform and automated image analysis.
Ulcerative colitis (UC) is characterized by disruptions of the gut microbiome and an exaggerated mucosal immune response in genetically susceptible individuals. Alterations in the composition of the intestinal metabolome associated with dysbiosis can trigger chronic inflammation. However, it remains…
Disentangling the hepatic risks of familial Mediterranean Fever and colchicine: A propensity score-matched analysis of 19,231 patients.
Familial Mediterranean Fever (FMF) is a monogenic autoinflammatory disease commonly treated with lifelong colchicine therapy. Although colchicine is considered safe, its long-term hepatic effects remain debated. Distinguishing liver injury attributable to FMF itself from that induced by colchicine i…
Impaired control of autoimmunity increases pediatric multiple sclerosis risk in EBNA-1-seropositives and -seronegatives.
Multiple sclerosis (MS) is an autoinflammatory disease of the central nervous system (CNS). Epstein-Barr virus (EBV) encodes for EBNA-1381-452, which induces autoreactive immune responses against distinct CNS derived proteins (GlialCAM370-389, CRYAB2-21, MBP205-224, ANO2135-154). Although EBV infect…
Factors Associated with Adalimumab Initiation in Non-Infectious Uveitis: A Propensity Score Matched Analysis.
To identify factors associated with adalimumab initiation in non-infectious uveitis. This was a retrospective case-control study using multicentric data of 3204 patients. The primary outcome was whether adalimumab was initiated, and the secondary outcome was time to initiation. To investigate factor…
Repurposing Lenalidomide for Refractory Behcet's Disease: Systematic Review and Computational Pharmacology Insights for Rare Disease Therapy.
Lenalidomide is an immunomodulatory drug. Its repurposing for refractory Behcet's Disease is a promising strategy. Behcet's Disease is a rare and complex autoinflammatory condition. Current treatment options are limited. This study explored the drug's therapeutic potential using clinical and computa…
PD-1 on CD8+T cells are low in Behçet's disease and is not normalised with type-I interferon.
Programmed cell death-1 (PD-1) protein on CD8+T cells may affect disease development as a regulatory molecule through various mechanisms. On the other hand, type-I interferons (IFN-I) are used in autoimmune and autoinflammatory diseases to induce regulatory mechanisms. This study aims to investigate…