Granulomatous inflammation in histopathological samples: examining the aetiological spectrum, diagnostic challenges, and future perspectives.
Granulomas can be found in different tissues and are associated with a variety of processes. To understand the primary diagnoses is the aim of this study. We retrospectively described a cohort of patients with a diagnosis of granulomas in histopathological samples over an 11-year period. Demographic…
Latest updates in quality of life and psychological impact of sarcoidosis.
Health-related quality of life (HRQoL) is now recognized as a major dimension to take into account for a holistic care of sarcoid patients. Accordingly, it has to be precisely and reliably evaluated all along disease evolution in order to prompt appropriate measure when needed. When significantly im…
Rhinologic Manifestations in Systemic Rheumatic Disease.
Sinonasal symptoms are a common early manifestation of several systemic inflammatory diseases and may precede multisystem involvement by days to years. Because nasal obstruction, drainage, epistaxis, crusting, and hyposmia are frequently attributed to chronic rhinosinusitis, diagnoses such as antine…
Rheumatologic diseases are systemic, immune-mediated disorders that frequently involve the larynx, producing manifestations that range from subtle dysphonia to life-threatening airway obstruction. Laryngeal involvement may precede systemic disease, progress despite adequate systemic control, or be t…
Pulmonary tuberculosis occurring during the diagnosis and treatment of sarcoidosis complicated by chylothorax: A case report.
Sarcoidosis is a systemic granulomatous disorder, and chylothorax is a rare but severe pleural complication of this disease and exhibits a prominent diagnostic overlap with tuberculosis. The present study reported the case of a 48-year-old woman who was admitted in May 2018 with chronic cough and ch…
Unveiling the unexpected: Skeletal sarcoidosis with an extraosseous soft-tissue mass in the ligamentous portion of sacroiliac joint.
Sarcoidosis is a chronic granulomatous, multisystem disease of uncertain etiology that affects various organ systems, although musculoskeletal involvement is rarely the dominant feature. We present the case of a woman in her 50s with a history of pulmonary sarcoidosis who developed new lower back an…
Multimodality Cardiovascular Imaging in the Evaluation of Cardiac Sarcoidosis.
Cardiac sarcoidosis (CS) is a granulomatous disease associated with increased cardiovascular risk, including symptomatic high-grade atrioventricular block, ventricular arrhythmia, heart failure, and sudden cardiac death. Diagnosis can be challenging and requires a high index of suspicion. Although e…
Tumefactive parenchymal lesion of neurosarcoidosis responsive to infliximab.
Neurosarcoidosis is an uncommon manifestation of systemic sarcoidosis and can involve any part of the nervous system. Intraparenchymal tumefactive lesions are particularly rare and pose a diagnostic challenge due to their radiographic resemblance to high-grade gliomas or metastatic disease. Optimal…